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Muscle Regenerative Medicine

Viss acts on human satellite cells .
“Regenerative medicine deals with repairing, regenerating or replacing tissues or organs damaged by disease, trauma or due to defects present at birth (congenital) or aging. Certainly a great impetus to the development of this new approach to medicine came, on the one hand, from the goals achieved by engineering and nanotechnologies applied to biomedicine; on the other, from studies on the use of stem cells , particular multipotent cells which, in appropriate conditions, are capable of regenerating tissues and organs.”
“Satellite cells have been defined as stem cells of adult skeletal muscle , this is because they have the function of maintaining tissue homeostasis, both in normal conditions and in the presence of damage and are simultaneously able to maintain their own population within of the fabric"

The most interesting feature of these cells lies in their ability to join together to generate new muscle cells . Muscle cells do not possess this characteristic and, although subject to continuous turnover, can only increase in size ( hypertrophy ) but not in number (hyperplasia).

After becoming operational, the satellite cells begin to divide and multiply, giving rise to myoblasts (embryonic progenitor cells of muscle cells). This first phase is called "satellite cell proliferation".

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The newly formed myoblasts fuse with the damaged muscle cells, giving them their nuclei (differentiation phase). The increase in the number of nuclei allows these cells to significantly increase protein synthesis, producing, among other things, more contractile proteins ( actin and myosin ) and more androgen receptors (hormones with anabolic effect).


Effects of Focused Vibrations on Human Satellite Cells

Silvia Sancilio 1,†, Sara Nobilio 1,†, Antonio Giulio Ruggiero 1, Ester Sara Di Filippo 2, Gianmarco Stati 1,3,

Stefania Fulle 2.3, Rosa Grazia Bellomo 4, Raoul Saggini 5 and Roberta Di Pietro 1.3,*


Abstract: Skeletal muscle consists of long plurinucleate and contractile structures, able to regenerate

and repair tissue damage by their resident stem cells: satellite cells (SCs). Reduced skeletal muscle

regeneration and progressive atrophy are typical features of sarcopenia, which has important health

care implications for humans. Sarcopenia treatment is usually based on physical exercise and

nutritional plans, possibly associated with rehabilitation programs, such as vibratory stimulation.

Vibrations stimulate muscles and can increase postural stability, balance, and walking in age and

sarcopenic patients. However, the possible direct effect of vibration on SCs is still unclear. Here,

we show the effects of focused vibrations administered at increasing time intervals on SCs, isolated

from young and aged subjects and cultured in vitro. After stimulations, we found in both young and aged subjects a reduced percentage of apoptotic cells, increased cell size and percentage of aligned cells, mitotic events, and activated cells. We also found an increased number of cells only in young samples. Our results highlight for the first time the presence of direct effects of mechanical vibrations on human SCs . These effects seem to be age-dependent, consisting of a proliferative response

Using Viss® as a maintenance program allows everyone to maintain efficient, young muscles and with optimal contractile capacity of the muscle fibers, in order to express their strength potential, improve posture and daily and sporting gestures
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